Three to four hours after last dosage, participants received either Ondexxya or placebo as a bolus or as a bolus plus a 2-hour infusion.2,3, The main efficacy outcome was the mean percent change in anti–FXa activity, which is a measure of FXa inhibition by the anticoagulant.2,3, Ondexxya rapidly reversed the anticoagulant activity of apixaban and rivaroxaban in healthy participants within minutes after administration and for the duration of infusion.4, Treatment with Ondexxya showed no evidence of clinical toxic effects.4, Please refer to the summary of product characteristics below and in the resource section for comprehensive information about the safety and effectiveness of Ondexxya (andexanet alfa) for the approved indication.5, 1. In adults with potentially life-threatening acute major bleeding, what is the efficacy and safety of andexanet alfa for reversing the anticoagulant effects of the factor Xa inhibitors apixaban, rivaroxaban, edoxaban, or enoxaparin? Looking to reduce costs at the pharmacy counter? Andexanet alfa, sold under the trade name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. Blood Adv. Results of ANNEXA-A and ANNEXA-R (NCT02207725 & NCT02220725) published … Andexanet Alfa (Andexxa) Formulary Review nih.gov Should you be in doubt, please contact us by email. Effective for the Fiscal Year 2019 starting October 1, 2018, the maximum NTAP for a case involving the use of Andexxa is $14,062.50, or 50 percent of the wholesale acquisition cost … There are no known drug interactions; Other Considerations. If you would like your order to be shipped by a specific courier, please inform us when you place the order. If you don't already have a prescription for this medicine, download our “Easy Prescription Guideline”. Generally, we do not support medical insurance, but we do provide you with an invoice after you make the payment that you may send to your medical insurance company so they can reimburse you. 5 g kit: ~ $3500 to 4200a a May vary by vendor. After you have accepted our offer, our experienced logistics team will arrange all the shipping and transportation of your medicine. In some countries we might also need an import license. Creating a password allows you to receive a quote and approve it or reject it in your dashboard. Disclaimer: The price indicated in USD ($) is an estimated price for your reference. The Named Patient support fee is tiered relative to the cost of the medicine. The free Drugs.com Discount Card works like a coupon and can save you up to Skip to the beginning of the images gallery, 100% successful deliveries to 87 countries, Yes, we have successfully delivered medicines to, By clicking "Download guide", you agree to receive emails from TheSocialMedwork (including the TheSocialMedwork newsletter and announcements). The safety and efficacy of repeat treatment with andexanet has not been established. We are experts in import regulations. Andexxa (coagulation factor Xa) (4 vials bolus + 5 vials infusion) The recommended dosing of Andexxa is based on the specific FXa inhibitor, dose of FXa inhibitor, and time since the patient's last dose of FXa inhibitor (see Table 2 ). However, a complication of treatment with these anticoagulants is major bleeding.2, Ondexxya (andexanet alfa) is a recombinant protein that has been designed to bind to FXa inhibitors. It works by binding and sequestering FXa inhibitors, making them unable to promote anticoagulation. Valid at all major chains including Walgreens, CVS Pharmacy, Target, WalMart Pharmacy, Reduced by 94% in the group that received an andexanet bolus, as compared to the 21% reduction that was seen in the placebo group, in participants receiving Apixaban. 400 mg, administered as an intravenous bolus at a target rate of 30 mg/min. Portola Pharmaceuticals press release, Apr 26, 2019, 2. Hereby it is able to rapidly reverse their blood-thinning effect, and to stop bleeding.2. We also highly recommend checking out local patient blogs, communities and patient organisations to find out more about your options. Arterial and venous thromboembolic events, Ischemic events, including myocardial infarction and ischemic stroke. We will walk you through the specific import regulations that are required for your shipping destination. Followed by administration of a continuous infusion of 8 mg/min for 120 minutes (960 mg). We operate solely under the TheSocialMedwork brand name. Portola reported $7.7 million of AndexXa sales in 3Q, 2018 (period ended September 30). In addition, shipping costs and a Named Patient support fee will apply. They welcomed me with open arms when I went to their office in Amsterdam. The manufacturer makes no recommendation regarding use during pregnancy.1, For a comprehensive list of side effects and adverse reactions please refer to the official prescribing information.1, 1. Scroll below to download the import guide for your country. Please note: This is a drug discount program, not an insurance plan. I truly appreciate their quick, efficient and professional attitude, as well as their patience and superb customer service…”, “I highly recommend TheSocialMedwork. Once we have verified your prescription and medical details, our expert sourcing team will work with our global network of suppliers to find you the best price. I was in a very difficult situation with a tight schedule, and their amazing team members…”. We will get in touch with you within 24 hours from Monday to Friday between 9:00 and 18:00 CET. European Commission Grants Conditional Marketing Authorization for Portola Pharmaceuticals’ Ondexxya™ (coagulation factor Xa (recombinant), inactivated-zhzo), the First and Only Antidote for the Reversal of Factor Xa Inhibitors
Select your preferred country and input your email to receive a step by step guide on how we can help you legally and safely import a medicine that is not approved in your country. 800 mg, administered as an intravenous bolus at a target rate of 30 mg/min. U.S. FDA Approves Portola Pharmaceuticals’ Andexxa®, First and Only Antidote for the Reversal of Factor Xa Inhibitors
Make an enquiry for more information. Once we have found you the lowest possible cost for your medicine, we will present you with a final offer for your approval. For any questions, make an enquiry and we'll be happy to help. In randomized clinical trials, factor Xa inhibitors have been shown to be safe and effective for the treatment and prevention of venous thromboembolism and for stroke prevention in patients with atrial fibrillation.1-4 However, factor Xa inhibitors have been associated with major and even fatal bleeding events.1-4 Such episodes of acute major bleeding may be difficult to treat because there is no reversal agent. The base cost of each medicine is set by the manufacturer. Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised cold chain couriers. Next we will also verify that you have a prescription from a doctor in your home country for the medicine you need. However, due to stock shortages and other unknown variables we cannot provide any guarantee. Fill out this form to enquire about Ondexxya (andexanet alfa). At a cost of $27k – $55k per dose, a 14% 30day mortality, and 10% thrombotic rate in a study excluding the sickest patients and no comparison arm, it is impossible to say if the andexanet alfa is causing this or just the disease process itself. The cost for a monthly or yearly treatment of Ondexxya (andexanet alfa) depends on your prescription requirements which includes the dosage in mg and medicine type ( 4 single-use vials). 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions. TheSocialMedwork provides access to Ondexxya (andexanet alfa) on the Named Patient import basis, which means that we work on behalf of the patient in cooperation with their treating doctor. therapeutically effective.8 Conversely, 1 dose of Andexxa will typically cost between $24,750 and $49,500 alone; it does not need to be administered alongside PCC or aPCC. The absence of a warning for a given medicine or combination thereof in no way should be construed to indicate that the medicine or combination is safe, effective or appropriate for any given patient. Ondexxya (andexanet alfa) was approved for the reversal of the anticoagulating effects of rivaroxaban and apixaban in patients with life-threatening or uncontrolled bleeding by: This is the first and only approved antidote for apixaban- or rivaroxaban-treated patients with uncontrolled bleeding.3, The EMA granted approval under conditional marketing authorisation, to support the development of and early access to medicines that address unmet medical needs of patients in the European Union.3, The FDA granted Andexxa with Orphan Drug and Breakthrough Therapy designations, to support the development of medicines which treat a serious or life-threatening condition and fill an unmet medical need.4. Collected information will not be shared with any third party and complies with our stated. discounted medicines to low income or uninsured and under-insured people who meet specific guidelines. For instructions on reconstitution of the medicinal product before administration, see section 6.6. The average cost difference is well over $20,000 or $53,100 when compared to low or high-dose Andexxa to PCC. It is estimated to cost ~ $4200 per reversal whereas it is estimated to cost $158000 per reversal with andexanet alfa. The estimated annual drug budget of treating 10–100 patients ranges from $248K to $495M. Reversal of Anticoagulation. Available for Android and iOS devices. We will never share your number with 3rd parties. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If you have any questions or need any help, contact our Patient Support Team. For the best experience on our site, be sure to turn on Javascript in your browser. Check if we have sent medicines to yours. You can read a detailed overview of prices and costs here. Turkey, Dear valued patients and customers,
Expand to see all locations within your area. Andexxa offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. The costs of low dose and high dose of Andexxa are approximately $29,040 and $58,080, respectively. If you have a question about its approval in a specific country feel free to contact our support team. When you buy Ondexxya (andexanet alfa), you can make the payment by bank transfer or by credit card. Here are some crowdfunding platforms where you can seek support: GoFundMe, GiveForward, FundRazr and Watsi. This is the first approved antidote for apixaban- or rivaroxaban-treated patients with uncontrolled bleeds. Our Named Patient support fee covers sourcing, logistics and following up to make sure that the order is received safely and in perfect condition. The cost for a monthly or yearly treatment of Ondexxya (andexanet alfa) depends on your prescription requirements which includes the dosage in mg and medicine type ( 4 single-use vials). This necessitates a bolus and an infusion. 30 minutes, followed by administration of a continuous infusion of 4 mg (low dose) or 8 mg (high dose) per minute for 120 minutes (see table 1). Please be aware that due to the COVID-19 situation worldwide and the country lockdowns, we will sometimes experience delays in shipping and shortages in availability. Andexxa is Portola's top drug candidate at the moment. Make an enquiry to receive information about the different options of obtaining for a patient in . Most patients received a single weight-based 4F-PCC dose of 25 units/kg (38.7%) or 50 units/kg (51.6%). The shipping fee might also include the cost of special packaging, such as coolboxes, cool packs and data loggers, as well as transport insurance to guarantee that you receive your medicine in good order. Clinical trial ANNEXXA-A (NCT02207725), last updated on Oct 1, 2018, 4. For more details, please see our article on cold chain delivery. Re: Kcentra cost versus Andexxa cost after NTAP The cost of Kcentra® is $1.27 per unit; a single dose of Kcentra® for an 80 kg patient costs $5,080. 800 mg at a target rate of 30 mg/min. Make an enquiry to receive information about the cost, shipping time and import details for . The price of the medicines you see on sale is the cost set by the manufacturer. Download Dosing Guide. It might be possible for you to claim the cost of Ondexxya (andexanet alfa) via your country's healthcare system. Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. In some limited circumstances, we do accept insurance. The cost doubles with high dose treatment (800 mg IV bolus plus 960 mg over 120-minute continuous infusion), with a total of $59,400. Dose * Initial IV Bolus Follow-On IV Infusion Total Number of 200 mg Vials Total Number of 100 mg Vials . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Please be aware that a 2.8% fee applies when paying by credit card. Thirty-one patients received 4F-PCC for major bleeding associated with apixaban (55%) or rivaroxaban (45%). It is available to order as well. The cost for Andexxa intravenous powder for injection (recombinant, inactivated 200 mg) is around $22,978 for a supply of 4 powder for injection, depending on the pharmacy you visit. The newer generation of blood thin… That is some hefty price tag. The most common adverse reactions (≥5% of patients) listed in the prescribing information include:1, The serious adverse reactions listed in the prescribing information include:1, It is not yet known if Ondexxya affects an unborn baby. For the best experience on our site, be sure to turn on Javascript in your browser. Aysen Simsek and her team offered assistance during a very difficult time. The shipping cost depends on the medicine and the destination country. Meant to act as a reversal agent for patients taking anticoagulants -- specifically Rivaroxaban and Apixaban -- Andexxa could prove to be a lifesaver for patients who suffer side effects of excessive, uncontrollable bleeding caused by the aforementioned drugs. It is given by injection into a vein.. Common side effects include pneumonia and urinary tract infections. They will be there to support and guide you in anyway possible to help you get the medicine you need. Reduced by 92% in the andaxanet bolus group, as compared to the 18% reduction seen in the placebo group, in participants receiving Rivaroxaban. A Study in Older Subject to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Rivaroxaban
Prices are for cash paying customers only and are not valid with insurance plans. Low Dose 400 mg at a target rate The half-life of andexanet is approximately 1 hour, after which point the factor Xa inhibitor levels rise and hemostasis is again impaired. Payments are fully encrypted and secure. Ondexxya (andexanet alfa) is a medication used for the treatment of patients treated with rivaroxaban or apixaban, when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding. We do not have any partnership with distributors, agents or any other entities. Andexxa Prices. See Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo). These effects were still seen when Andexxa was given as a bolus plus an infusion. To reduce this risk, resumption of anticoagulant therapy should be considered as soon as medically appropriate.1, Complete information about Ondexxya (andexanet alfa) dosage and administration can be found in the official prescribing information listed in our references section.1. Based on the average mean dose in a retrospective study of 4-Factor PCC in FXa inhibitor-related bleeding, it could cost around $4973 per treatment [40]. Crowdfunding might also be an option for you. Any hospital wishing to keep andexanet in stock should keep three flats on hand at all times in order to be adequately stocked to administer the high-dose regimen, which is an 800mg bolus plus a 8 mg/min infusion for 2 hours, which totals 960mg. Please check your spam or junk folder. These numbers are from Cardinal Health as of January 7, 2019. FXa is a protein that helps blood clot, and its inhibitors are used to have an anticoagulant (blood-thinning) effect. Full prescribing information [EMA]: Ondexxya (andexanet alfa) [PDF]
By Marina Haque, Michael Gratson & 2 more. To date, we have assisted patients in over 80 countries to access thousands of life-improving medicines. Create an account with us to view and manage your quotes, import documents, prescriptions and more. From your side, we’ll simply need a prescription from your treating doctor. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. 4.3 Contraindications. We comply with the HONcode standard for trustworthy health information -, Drug class: anticoagulant reversal agents, Here are 10 ways to save money on prescription drugs. • Cost - ~$27,500 to $50,000 per dose ANDEXXA® (coagulation factor Xa (recombinant), inacti vated-zhzo) package insert. The shipping fees may include the shipping from our supplier to our partner pharmacy as well as the shipping costs to deliver the medicine to the patient’s country of residence. Our standard delivery time varies from 5 to 10 working days. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Alexion Pharmaceuticals, May 3, 2018, 2. Note: Please consult with your treating doctor for personalised dosing. The European Medicines Agency (EMA), Europe, on April 26, 2019. 8 mg/min for up to 120 minutes (960 mg) 9. Full prescribing information [EMA]: Ondexxya (andexanet alfa) [PDF]
Make an enquiry and we will help you calculate the total price to buy Ondexxya (andexanet alfa) online and have it delivered where you live. Intracranial hemorrhage (58%) and pericardial effusion (16%) accounted for the majority of bleeding events. Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or This Andexxa price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies. The Food and Drug Administration (FDA), USA, with accelerated approval under the brand name Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo) on May 3, 2018. Our Patient Support Team will contact you within two hours between 9:00 and 18:00 CET from Monday to Friday. Select one or more newsletters to continue. J7333 Hyaluronan or derivative, visco-3, for intra-articular injection, per dose. Our Patient Support team will guide you throughout the process. Ondexxya (andexanet alfa) was approved by the FDA in May 2018 under the trade name Andexxa (coagulation factor Xa (recombinant), inactivated-zhzo). Use this coupon to get this price at any WALMART PHARMACY location. Submit a request for a specific medicine, or a general request, and your Patient Support Manager will contact you within 24 hours. The best thing would be to check with your country's own health ministry. Witt DM et al. A Study in Older Subjects to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Apixaban
At the time of writing, andexanet is $22,000 per package of four 200mg vials. When paying by credit card, you can pay online once you have received your order confirmation. Some countries have a government fund providing financial assistance for citizens to access lifesaving medical treatment abroad. Cost: $307 per 5 mL vial (5) Collected information will not be shared with any third party and complies with our stated Privacy Policy. Drug Interactions. Dose: slow IV injection, IV dose is dependent on heparin dose given in the last 3-4 hours (1 mg protamine for 100 units heparin), doses not to exceed 50 mg of protamine sulfate in any 10 minute period (can cause severe, hypotensive or anaphylactoid reactions), usually not more than 100 mg in short period (3, 4). In addition, shipping costs and a Named Patient support fee will apply. Always consult your treating physician before starting a course of treatment. European Commission Grants Conditional Marketing Authorization for Portola Pharmaceuticals’ Ondexxya™ (andexanet alfa), the First and Only Antidote for the Reversal of Factor Xa Inhibitors
They are reliable, honest, punctual and do everything to meet your needs…”, “Dr. WALMART PHARMACY. After making an enquiry, you will receive a detailed quote that includes the shipping costs. Within 2 minutes following the IV bolus, administer the continuous IV infusion for up to 120 minutes. For that reason, cold chain shipping can be more expensive than regular shipping. The Woodlands, TX 77384. (Page 1 Executive Summary line 8-9). Dose > 10 mg > 5 mg . Here are 10 ways to save money on prescription drugs. Please note that this medicine may have also been approved in other regions than the ones we’ve listed. Generally, our Named Patient support fee, shipping costs and any local tax (if applicable) are not included in the product price that is displayed on our website unless stated otherwise. You can pay by bank transfer or credit card. J7169 Injection, coagulation factor xa (recombinant), inactivated-zhzo (andexxa), 10 mg. J7204 Injection, factor viii, antihemophilic factor (recombinant), (esperoct), glycopegylated-exei, per iu. We are registered and audited by the Dutch Ministry of Health in The Hague as an Independent Intermediary for Medicines, registration number 6730 BEM and as a Pharmaceutical Distributor with the registration number 16258 G. We support the United Nation’s 2030 Sustainable Development Goals related to Health and Equality. How and where to buy Ondexxya: You can order Ondexxya from TheSocialMedwork if the drug has not been approved or is not available in your country. You will receive an email with a download link to your guide (or a confirmation if you selected Other) at [email protected]. Since we help patients access medicines not available in their home country, our first step is to check that the medicine you need is not currently available in your home country. We support you to access approved medicine that is not approved or available in your country of residence. Important: When there is a range of pricing, consumers should normally expect to pay the lower price. 2018; 2 (22):3257-91. We have delivered medicines to more than 88 countries. There are currently no Manufacturer Promotions that we know about for this drug. Followed by administration of a continuous infusion of 4 mg/min for up to 120 minutes (480 mg). Based on the average mean dose in a retrospective study of 4-Factor PCC in FXa inhibitor-related bleeding, it could cost around $4973 per treatment [40]. The wholesale acquisition cost of the standard dose regimen is $24,750, and the high-dose regimen is $49,500. Andexxa(c) needs to be reconstituted prior to use; the manufacturer recommends slowly injecting 10 mL of water into the vial containing the powder and allowing 3-5 minutes for the powder to dissolve. Some medicinal ingredients are susceptible to damage from heat, light and handling. The wholesale acquisition cost of the standard dose regimen is $24,750, and the high-dose regimen is $49,500. Get Coupon. The estimated annual drug budget of treating 10-100 patients ranges from $248K to $495M. There are currently no Patient Assistance Programs that we know about for this drug. But again, this is reserved for life threatening situations. 6,9 While data suggest that Andexxa may be highly Thromboembolism is obstruction in vessels due to formation of blood clots. Please beware of fraudulent websites, communications and typo deviations used by fraudulent providers claiming to represent TheSocialMedwork. 8 mg/min for up to 120 minutes (960 mg) 9 (4 vials bolus + 5 vials infusion) *The safety and effectiveness of more than one dose have not been evaluated. Low titers of anti-ANDEXXA antibodies were observed in 26/145 healthy subjects (17%); 6% (9/145) were first observed at Day 30 with 20 subjects (14%) still having titers at the last time point (Days 44 to 48). or obtaining a sample from the doctor's office. The costs of low dose and high dose of Andexxa are approximately $29,040 and $58,080, respectively. Eligibility requirements vary for each program. is a member of the anticoagulant reversal agents drug class and is commonly used for JavaScript seems to be disabled in your browser. Medicine information contained herein may be time sensitive. Scroll below to download the import guide for your country. The price of the medicines you see on sale is the cost set by the manufacturer. ~ $1.60 to 2.77 per unit: $1.64/unita a May vary by vendor. Siegal DM, New England Journal of Medicine, Dec 17, 2015, 3. Our Patient Support Team will personally assist you along the way, Ondexxya (andexanet alfa), is a Factor Xa inhibitor reversal agent indicated for patients treated with rivaroxaban and apixaban, when rapid reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.1, It is available in lyophilized powder form in single-use vials of 200 mg or 100 mg of andexanet alfa.1, Factor Xa (FXa) inhibitors such as apixaban and rivaroxaban are widely used in the clinic to prevent and to treat thromboembolism. 800 mg at a target rate of 30 mg/min. Total costs were $143 193 for warfarin, $164 576 for low-dose dabigatran, and $168 398 for high-dose dabigatran. With Andexxa being the only reversal agent of its kind, it's easy to see why some investors consider the drug to be the home run that Portola's been looking for. Adult Dosage: For IV use only. Andexanet alfa (andexanet) has been designed and developed specifically to reverse the effects … Andorra, Argentina, Australia, Austria, Azerbaijan, Bahrain, Belarus, Brazil, Bulgaria, Cambodia, Canada, Chile, China, Colombia, Costa Rica, Croatia, Cyprus, Denmark, Dominican Republic, Egypt, Estonia, Finland, France, Georgia, Germany, Ghana, Greece, Guatemala, India, Iraq, Ireland, Israel, Italy, Jamaica, Japan, Jordan, Kenya, Kuwait, Latvia, Lebanon, Libya, Lithuania, Malawi, Mexico, Montenegro, Nepal, Netherlands, New Zealand, Nigeria, Norway, Oman, Pakistan, Paraguay, Peru, Poland, Qatar, Romania, Saudi Arabia, Serbia, Singapore, Slovenia, Spain, Sri Lanka, Sudan, Sweden, Switzerland, United Arab Emirates, United Kingdom, United States, Venezuela, Zimbabwe, Åland Islands, Afghanistan, Albania, Algeria, American Samoa, Angola, Anguilla, Antarctica, Antigua & Barbuda, Armenia, Aruba, Bahamas, Bangladesh, Barbados, Belgium, Belize, Benin, Bermuda, Bhutan, Bolivia, Bosnia & Herzegovina, Botswana, Bouvet Island, British Indian Ocean Territory, British Virgin Islands, Brunei, Burkina Faso, Burundi, Cameroon, Cape Verde, Cayman Islands, Central African Republic, Chad, Christmas Island, Cocos (Keeling) Islands, Comoros, Congo - Brazzaville, Congo - Kinshasa, Cook Islands, Cuba, Czechia, Côte d’Ivoire, Djibouti, Dominica, Ecuador, El Salvador, Equatorial Guinea, Eritrea, Eswatini, Ethiopia, Falkland Islands, Faroe Islands, Fiji, French Guiana, French Polynesia, French Southern Territories, Gabon, Gambia, Gibraltar, Greenland, Grenada, Guadeloupe, Guam, Guernsey, Guinea, Guinea-Bissau, Guyana, Haiti, Heard & McDonald Islands, Honduras, Hong Kong SAR China, Hungary, Iceland, Indonesia, Isle of Man, Jersey, Kazakhstan, Kiribati, Kyrgyzstan, Laos, Lesotho, Liberia, Liechtenstein, Luxembourg, Macao SAR China, Madagascar, Malaysia, Maldives, Mali, Malta, Marshall Islands, Martinique, Mauritania, Mauritius, Mayotte, Micronesia, Moldova, Monaco, Mongolia, Montserrat, Morocco, Mozambique, Myanmar (Burma), Namibia, Nauru, New Caledonia, Nicaragua, Niger, Niue, Norfolk Island, North Korea, North Macedonia, Northern Mariana Islands, Palau, Palestinian Territories, Panama, Papua New Guinea, Philippines, Pitcairn Islands, Portugal, Russia, Rwanda, Réunion, Saint Barthélemy, Samoa, San Marino, Senegal, Seychelles, Sierra Leone, Slovakia, Solomon Islands, Somalia, South Africa, South Georgia & South Sandwich Islands, South Korea, St. Helena, St. Kitts & Nevis, St. Lucia, St. Martin, St. Pierre & Miquelon, St. Vincent & Grenadines, Suriname, Svalbard & Jan Mayen, Syria, São Tomé & Príncipe, Taiwan, Province of China, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tokelau, Tonga, Trinidad & Tobago, Tunisia, Turkmenistan, Turks & Caicos Islands, Tuvalu, U.S. Outlying Islands, U.S. Virgin Islands, Uganda, Ukraine, Uruguay, Uzbekistan, Vanuatu, Vatican City, Vietnam, Wallis & Futuna, Western Sahara, Yemen, Zambia, Iran,